Audit Committee Compensation Committee Nominating and Corporate Governance Committee R&D Committee Edgar Engleman, M.D. R&D Committee James Healy, M.D., Ph.D. Independent Director Nominating and Corporate Governance Committee R&D Committee Kathleen LaPorte Audit Committee Frank D. Lee Compensation Committee Nominating and Corporate Governance Committee Richard A. Miller, M.D. Compensation Committee Nominating and Corporate Governance Committee R&D Committee Brian O'Callaghan Audit Committee Compensation Committee Nicole Onetto, M.D. R&D Committee Randall C. Schatzman, Ph.D. Mahendra G. Shah, Ph.D. Audit Committee Nominating and Corporate Governance Committee = Lead Independent Director = Chairperson = Member = Financial Expert
