Bolt Biotherapeutics is a clinical-stage immuno-oncology company developing tumor-targeted therapies that leverage the power of the innate and adaptive immune systems. Bolt’s proprietary Boltbody™ Immune-stimulating Antibody Conjugate (ISAC) approach uses immunostimulants to engage and activate myeloid cells that directly kill tumor cells. This leads to the conversion of immunologically “cold” tumors to “hot” tumors.
Our lead clinical-stage candidate, BDC-1001, is a Boltbody ISAC comprised of a HER2-targeting biosimilar of trastuzumab conjugated to one of our proprietary TLR7/8 agonists for the treatment of patients with HER2-positive solid tumors. Data from our completed Phase 1 dose-escalation trial support the advancement of BDC-1001 into Phase 2 studies.
Bolt is also advancing BDC-3042, a proprietary myeloid modulating agonistic antibody targeting Dectin-2. BDC-3042 is designed to reprogram tumor-associated macrophages (TAMs) into immunostimulatory cells that enhance innate and adaptive anti-tumor immunity. Preclinical data support the advancement of BDC-3042 into the clinic in 2023.
May 25, 2023
Bolt Biotherapeutics Highlights Comprehensive Clinical Data from Phase 1 Dose-Escalation Trial of BDC-1001 as Monotherapy and in Combination with Nivolumab in HER2-Expressing Tumors at 2023 ASCO Annual MeetingRead More
May 11, 2023
Bolt Biotherapeutics Reports First Quarter 2023 Financial Results and Provides Business UpdateRead More
April 26, 2023
Bolt Biotherapeutics to Present Clinical Data from Phase 1 Dose-Escalation Trial of BDC-1001 in HER2-Expressing Tumors at 2023 ASCO Annual MeetingRead More
June 3, 2023 at 9:00 AM EDT
2023 American Society of Clinical Oncology (ASCO) Annual Meeting Read More
April 17, 2023 at 1:30 PM EDT
American Association of Cancer Research (AACR) Annual Meeting 2023 Read More
March 7, 2023 at 2:50 PM EST
Cowen 43rd Annual Healthcare Conference Read More