Corporate Overview

Bolt Biotherapeutics is a clinical-stage immuno-oncology company developing tumor-targeted therapies that leverage the power of the innate and adaptive immune systems. Bolt’s proprietary Boltbody™ Immune-stimulating Antibody Conjugate (ISAC) approach uses immunostimulants to engage and activate myeloid cells that directly kill tumor cells. This leads to the conversion of immunologically “cold” tumors to “hot” tumors.

Our lead clinical-stage candidate, BDC-1001, is a Boltbody ISAC comprised of a HER2-targeting biosimilar of trastuzumab conjugated to one of our proprietary TLR7/8 agonists for the treatment of patients with HER2-expressing solid tumors. We believe that our preliminary Phase 1/2 data from our ongoing clinical trial provide us with clinical proof of concept for our HER2 Boltbody ISAC approach.

Bolt is also advancing BDC-3042, a proprietary myeloid modulating agonist antibody targeting Dectin-2.


August 31, 2022

Bolt Biotherapeutics to Present at Morgan Stanley 20th Annual Global Healthcare ConferenceRead More

August 10, 2022

Bolt Biotherapeutics Reports Second Quarter 2022 Financial Results and Provides Business UpdateRead More

May 27, 2022

Bolt Biotherapeutics to Present Ex Vivo Data Characterizing the Myeloid Cell Landscape in Solid Tumors at ASCO 2022Read More

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September 13, 2022 at 12:20 PM EDT

Morgan Stanley 20th Annual Global Healthcare Conference Read More

June 5, 2022 at 9:00 AM EDT

The 2022 American Society of Clinical Oncology (ASCO) Annual Meeting Read More

April 14, 2022 at 3:45 PM EDT

21st Annual Needham Virtual Healthcare Conference Read More

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