United States securities and exchange commission logo

                         April 6, 2022

       Randall C. Schatzman, Ph.D.
       Chief Executive Officer
       Bolt Biotherapeutics, Inc.
       900 Chesapeake Drive
       Redwood City, California 94063

                                                        Re: Bolt
Biotherapeutics, Inc.
Statement on Form S-3
                                                            Filed March 30,
                                                            File No. 333-263994

       Dear Dr. Schatzman:

               This is to advise you that we have not reviewed and will not
review your registration
       statement. Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Abby
Adams at (202) 551-6902 with any questions.


                         Division of Corporation Finance

                         Office of Life Sciences
       cc:                                              John McKenna, Esq.